3D Imaging of Fine Needle Aspirates Using Optical Projection Tomographic Microscopy

Computerized Diagnosis of Breast Fine-Needle Aspirates

The goal of this work is to determine the accuracy of computer-based image analysis in diagnosing breast fine-needle aspirates (FNA). On 192 FNAs, the computerbased diagnostic accuracy was 97.9%. This is consistent with the 97.5% accuracy projected by machine learning methods during the initial training in 1994 with 569 FNAs. One of the attributes of this system is the rendering of a value that...

Transmission electron microscopy of percutaneous fine needle aspirates from lung: a study of 70 cases.

Seventy consecutive lung fine needle aspirates (FNA) from 69 patients were examined by cytology/cell block histology, by transmission electron microscopy (TEM), and, where available, at histological follow up to determine the value of TEM in interpreting lung FNAs. Of 70 FNAs, 50 were suitable for TEM. Transmission electron microscopy was helpful in classifying seven of 10 poorly differentiated...

Optical fine-needle imaging biopsy of the brain.

We demonstrate optical fine-needle imaging biopsy (FNIB), combining a fine needle (22 gauge) and a high-resolution side-view probe (350-μm diameter) for minimally invasive interrogation of brain tissue in situ. We apply this technique to examine pathogenesis in murine models of neurodegeneration, brain metastasis of melanoma, and arterial occlusion, respectively. The demonstrated ability to obt...

Cryoimaging-Microscopy Implementation for 3D Optical Imaging

Molecular Markers in Fine Needle Aspirates of the Thyroid

When Policy Topic is covered The use of the Afirma Gene Expression Classifier in fine needle aspirates of the thyroid that are cytologically considered to be indeterminate (follicular lesion of undetermined significance or follicular neoplasm) may be considered medically necessary in patients who have the following characteristics:  Thyroid nodules without strong clinical or radiologic finding...